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All Journal Jurnal Kesehatan Lingkungan indonesia e-Journal Pustaka Kesehatan Journal of Agromedicine and Medical Sciences Journal of Islamic Medicine Indonesian Journal for Health Sciences (IJHS) JPIn : Jurnal Pendidik Indonesia Buletin Poltanesa
Kristianningrum Dian Sofiana
Departemen Fisiologi, Fakultas Kedokteran, Universitas Jember
Agriculture, Biological Sciences & Forestry Computer Science & IT Education Environmental Science Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Efek Pemberian Vitamin E (d-α-tocopherol) terhadap Memori Kerja Spasial Tikus (Rattus novergicus) Remaja yang Diinduksi Etanol Shera Nadhila Setyo Bisono; M. Ihwan Narwanto; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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During neurogenesis process, nerve cells especially hippocampus susceptible to damage when exposed to ethanol. Vitamin E is an antioxidant and capable to protect nerve cells damage. This study aimed to determine the effect of vitamin E (d-α-tocopherol) on spatial working memory of adolescent rats induced with ethanol. The study used 30 days-old rats (Rattus novergicus), weight between 50-100 grams. Total of 25 rats were divided into 5 groups: 2 control groups and 3 treatment groups. K1/K(-) was normal group without ethanol and vitamin E, and K2/K(+) were induced with ethanol. The treatment groups were given ethanol and vitamin E at a dose of 100mg/kgBW; 200 mg/kgBW; 400 mg/kgBBW respectively for P1, P2 and P3. After treatment for 14 days, the rats were tested for spatial working memory using the Radial Arm Maze (RAM) for 10 consecutive days. Spatial working memory was observed by the total number of right arm option which were entered by rats. The average number of right arm maze option for 10 days, were; K (-): (7 ± 0.52), K (+): (3.98 ± 0.66), P1: (4 , 56 ± 0.41), P2: (6.76 ± 1.01) and P3 (6.38 ± 0.63). In conclusion, there was an effect of vitamin E at a dose of 200 mg/kgBW and 400 mg KgBW on spatial working memory of ethanol-induced adolescent rats.   Keywords: ethanol, vitamin E, spatial memory, Radial Arm Maze
Efek Preventif Ekstrak Etanol Kopi Robusta (Coffea canephora) terhadap Peningkatan Kadar Kolesterol Total Tikus Jantan Galur Wistar yang Diinduksi Kuning Telur Yan Agus Achtiar; Hairrudin Hairrudin; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Kopi robusta mengandung asam klorogenat (CGA) sekitar 7-14%. Asam klorogenat diduga dapat mencegah penyerapan kolesterol diusus. Penelitian ini bertujuan untuk membuktikan efek preventif ekstrak etanol kopi robusta (Coffea canephora) terhadap peningkatan kadar kolesterol total tikus. Penelitian ini adalah penelitian eksperimental laboratorium pre-post-test dengan kelompok kontrol. Dua puluh emapt ekor tikus wistar jantan usia 3-4 bulan, dibagi menjadi kelompok perlakuan K1 diinduksi kuning telur, kelompok K2 diinduksi kuning telur dan ekstrak kopi dosis terapi (0,5 mL / ekor), kelompok K3 diinduksi kuning telur dan simvastatin, kelompok K4 diinduksi kuning telur dan ekstrak kopi dosis tinggi (1 mL / ekor) selama 35 hari. Pada awal dan akhir perlakuan diambil serum darah untuk mengetahui kadar kolesterol total darah menggunakan menggunakan metode CHOD-PAP. Dalam waktu 35 hari, pemberian ekstrak kopi robusta tidak mencegah kenaikan kadar kolesterol total. Sehingga dapat disimpulkan bahwa tidak ada efek preventif ekstrak etanol kopi robusta (Coffea canephora) terhadap peningkatan kadar kolesterol total tikus wistar jantan yang diinduksi kuning telur.   Kata kunci: Hiperkolesterolemia, asam klorogenat, kolesterol total serum
Jumlah Makrofag pada Luka Insisi Full Thickness yang diberi Ekstrak Umbi Bidara Upas (Merremia mammosa (Lour)) pada Tikus Wistar Jantan (The Number of Macrophage in Full Thickness Wound Incision after Treatment using Merremia mammosa Extract in Male Wist Fajar Kurniawan Hidayat; Ulfa Elfiah; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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One important complication in the diabetic patient is diabetic ulcer. Diabetic ulcers in diabetes patient can increase the risk of amputation and expensive treatment costs, so the alternative treatmeant such as Merremia mammosa which has antiinflamatory and antidiabetic is needed. This study aimed to determine the comparison of the number of macrophage in the incisional wound in hyperglycemic male wistar rats between treatment with Merremia mammosa extract and NaCl. The in vivo test was done by creating wound incision on the mice backs and treated with gentamycin ointment 5% in a positive control group, NaCl in a negative control group and Merremia mammosa extract in a dose of 100m), 200mg, 400mg in treatment group. The result obtained by counting the number of macrophage in histopatholgy examination. The result showed the number of macrophage were 0,36 cells/field of view in a negative control group, 0,52 cells/field of view in a positive control group, 0,48 cells/field of view in all Merremia mammosa treatment groups. The data analysis showed no significant difference with p-value of 0,729. In conclusion, there was no significant difference between the used of Merremia mammosa extract and NaCl on full thickness incisional wounds of hyperglycemic male wistar rats.   Keywords: Diabetes Mellitus, Merremia mammosa extract, incisional wound
Respon Imunogenitas Antibodi Poliklonal IgY terhadap Protein Adhesi Pili 95 kDa Shigella dysenteriae asihanti rosita ferdiana; Enny Suswati; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Shigella dysenteriae is the most frequently cause of deaths of dysentery cases in infants and toddlers. Shigella dysenteriae has a pili that act as an adhesin molecule and will detect in human body as antigens which is involved in producing antibodies. This study was conducted to prove that Shigella dysenteriae pili adhesion protein 95 kDa is immunogenic. This was an experimental laboratory study with quasy experimental design in vitro. The study began with mice erythrocyte cell isolation, IgY polyclonal antibodies isolation, mice intestinal enterocytes cell isolation, hemagglutination inhibition test, and adhesion inhibition test. The haemagglutination inhibition test showed that the pili adhesion protein 95 kDa of S. dysenteriae able to inhibit the haemagglutination of erythrocytes mice Balb/C up to ½ dilution. While, the adhesion inhibition test revealed that the fewer of antibody concentration on enterocytes, the greater bacteria attached. According to the linear regression test results, the index adhesion value increased along with the decreased of antibody concentration. In conclusion, pili adhesion protein 95 kDa from S. dysenteriae was immunogenic and could inhibit the hemagglutination and adhesion between S. dysenteriae and mice enterocytes cells.   Keywords: immunogenicity, IgY polyclonal antibody, Shigella dysenteriae, pili adhesion protein.
Pengaruh Terapi Kombinasi Ekstrak Etanol Mentimun (Cucumis sativus) dan Vildagliptin terhadap Penurunan Kadar Glukosa Darah Tikus Wistar yang Diinduksi Aloksan (The Effect of Combination Treatment of Cucumber (Cucumis sativus) Ethanolic Extract and Vilda Chita Setya Widyani; Sugiyanta Sugiyanta; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Effective management is needed. Cucumber is one of traditional medicine contains saponins with antihyperglycemic effects. This study aimed to determine the differences between combination therapy of cucumber ethanolic extract and vildagliptin and monotherapy of cucumber ethanolic extract or vildagliptin to decrease the blood glucose. The rats were injected with alloxan 125 mg/kgBW. There were 5 groups: K1 was normal group, K2 was a group of diabetic rats without treatment, K3 was a group of diabetic rats with cucumber ethanolic extract (200 mg/kgBW), K4 was a group of diabetic rats with vildagliptin treatment (1,8 mg/200 gBW), K5 was a group of diabetic rats with combination treatment of cucumber ethanolic extract (200 mg/kgBW) and vildagliptin (1,8mg/200 gBW). After 14 days, fasting blood glucose (FBG) was measured. The result showed that the mean FBG after treatment (FBG 2) of K1, K2, K3, K4, and K5 were (82,4; 277,2; 188,2; 199,2; 180,6) mg/dL, respectively. In conclusion, the potential of cucumber ethanolic extract and vildagliptin in combination treatment was more effective to decrease the blood glucose levels than both monotherapy of cucumber ethanolic extract or vildagliptin in Wistar rats.   Keywords: Diabetes Mellitus, Cucumber, Vildagliptin, Blood Glucose Levels, Alloxan
Co-Authors asihanti rosita ferdiana Bagus Hermansyah Chita Setya Widyani Dini Agustina ENNY SUSWATI Fajar Kurniawan Hidayat Fajar Kurniawan Hidayat Fajar Kurniawan Hidayat, Fajar Kurniawan Hairrudin Hairrudin Jauhar Firdaus Khotimah Husnul Komang Yunita Wiryaning Putri Laila Rizqi Kurniawati Laksmi Indreswari M Aris Widodo M. Ali Shodikin M. Ihwan Narwanto Muhammad Hasan Muhammad Ryznar Faisal Nur Luqmani Musdalifana Vega Ratrinda Pralampita, Pulong Wijang Prasetya, Moch.Arief Prasetyo, Aris Provisia Marthalita Y.W. Shera Nadhila Setyo Bisono Sofiannisa Achmadila Sugiyanta Sugiyanta Supangat Supangat Ulfa Elfiah Yan Agus Achtiar Yudha Nurdian Zahrox, Iin Fatimatus